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KMID : 0356919940270050421
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Korean Journal of Anesthesiology
1994 Volume.27 No. 5 p.421 ~ p.427
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The Changes of Arterial Ketone Body Ratio and Osmolal Gap during Hemorrhagic Shock in Rabbit
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김일환
이경우/최영균/김영재/박진우/신치만/박주열
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Abstract
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The ratio of acetoacetate to β-hydroxybutyrate (Ketone body ration) in the blood may reflects the mitochondrial free NAD+/NADH ration in the liver.
Also arterial ketone body ration will reflects the energy status of the hepatocytes, because mitochondrial free NAD+/NADH ratio is closely related to oxidative phosphorylation.
Arterial ketone body ratio and osmolal gap, the difference between measured osmolality and calculated osmolality, were measured 30 min after the induction of hemorrhagic shock with mean arterial blood pressure at 40 mmHg in ten rabbits.
Arterial ketone body ratios decreased significantly (p<0.05) from 0.74±0.17 to 0.38±0.09 and osmolal gap increased significantly (p<0/05) from 17.7±5.9 mOsm/Kg to 32.8±12.3 mOsm/Kg at 30 min after the induction of hemorrhagic shock.
These results suggest that in hemorrhagic shock, decreased arterial ketone body ration which reflects the inhibition of the TCA cycle is associated with increase of osmolal gap.
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